Based on a couple of sentences in the thread linked to above about my bed and bumper swap (it's been 5 years, so I don't remember the details), I took the bed off before I removed the bumper. Bed removal is pretty straightforward. No need to remove the aftermarket Curt hitch for either bed removal or bumper removal. The bed itself, minus the tailgate, probably weighs 150 lbs at most. The tailgate is maybe 75 lbs.
If you're asking if the factory bed cover can be removed by one person, yes - just don't plan to carry it far. I remember reading once that they weigh 85 lbs. I took one off by myself earlier this year at a salvage yard. It is doable, but the cover is a beast - heavy and too big to really get a good hold of.