The new ignition cylinder will come with 2 PATS keys. If you have 2 working ignition keys right now then programming the new ones won't be too challenging. First you need to have all the door closed and locked. Then using one of the working keys, turn the truck to run (don't start). Let it sit until the theft light turns off, maybe 30 seconds or so. Then turn back to off, switch to the second working key and repeat turning to run and waiting for theft light to turn off. You are now in programming mode. Pull the ignition cylinder out, swap in the new one with key and turn from lock to run. When theft light turns off the key is recognized. Turn back to lock and swap in second new key. Repeat turning to run and again wait for system to recognize the key. Start truck to end programming mode and verify keys work. Done in about 4-5 minutes.
If you have trouble trying to swap out the cylinders quickly enough for whatever reason, you can go route 2 which needs a little more prep, maybe 10 minutes: Take off the plastic column shroud by removing the 3 phillips screws from the bottom, unscrewing the tilt lever (its actually a steel bolt with knurled handle), and popping the top/bottom apart. Swap the cylinders as noted before leaving 1 new key in place. Now look at the lock cylinder. You will see there is a green or blue plastic "c"-shaped sensor with a wire running to it sitting on the cylinder. This the PATS key reader. You can pull it off the cylinder and hold it against the keys as you go through the off/on sequence. Start with sensor against the old working keys one at a time, then the new loose key and end by puting the sensor back in place and turning with the new key you have in the ignition. Once finished, snap the column covers back on, replace screws and tilt lever.