What "nuts" are you referencing? The nut holding the impeller to the shaft? Did the nuts back off ont heir own or did the shaft break at/near the nut? You need to be very clear around here and provide background details, lest people jump to all kinds of conclusions that are, at best, just wrong or, at worst, WTF are they talking about...
Is everything OEM or do you have a tune (i.e. running more than standard boost levels)?
I've had a few turbos over the years. The only ones I've had that broke shafts were the ones that were run with excessive overboost and it takes it's toll on turbos. It's part of the price you pay for "moar" power.
The few others I've seen with broken/seized shafts were almost always oil related issues or other abuse. Usually the shaft breaks, sometimes at/near the nut, sometimes near the middle. I can't say I've ever seen any where the nuts have just loosened on their own though.