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Ford Explorer Community - Maintenance - Modifications - Performance Upgrades - Problem Solving - Off-Road - Street
Explorer Forum Covers the Explorer ST, Explorer Sport, Explorer Sport Trac, Lincoln Aviator, Mercury Mountaineer, Mazda Navajo, Ford Ranger, Mazda Pickups, and the Ford Aerostar
I had similar issues and it was the CV on the front driveshaft. I'm not sure how your 00 compares to mine but on mine the CV joint got enough play in it that the driveshaft would vibrate at highway speeds.
They're easy to check, just slide under there and try to shake them.