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A true misfire is usually due to a bad sparkplug. However, you can be getting misfire-like symptoms from a dirty Mass Air Flow Sensor (MAS/MAF) and other components. I'd check the plugs and clean your MAS and see what happens. 46k is a bit early for a plug change, but it might be time to change your plugs and wires.
For the benefit of other users and so that other can help, I'm gonna copy your email here:
Thank you for replying to my message. Perhaps I could have better identified the problem as an intermittent skip. The skip happens sometimes usually while going up a grade. The check engine light has not come on. The engine start fine and idles fine too.
Nothing jumps into mind as to what could be a definitive root of your problem. Hopefully someone else has an idea.