Okay, with the thermo tested and installed properly (spring towards engine, weep hole up top) you fill the system with your 50/50 mix.
keep going till all air bubbles purge, squeeze the upper and lower hoses, this helps.
Now start the engine with the rad cap off
run it at idle for a few minutes.
You will see air bubbles being purged
once it starts getting really warm and rising put the cap on it, run it to operating temp.
Fill your overflow with 50/50 and you should be good to go.
If air is trapped behind the thermostat it will never open, truck will get hot quickly.
You can boil water and pour it down the upper radiator hose, this will open the thermo and release any trapped air.