Yes, I have 265-75-16s all the way around. In the rear, they bolted on no problem. In the front, while I was getting the tires mounted, the guy did a slight torsion twist and shimmed the front bumper out with washers (four regular washers per bolt) instead of cutting the lower plastic. What's funny is that you can't even tell the bumper is shimmed out slightly. The torsion twist is free and the washers for the four bolts that hold the bumper on cost less that a dollar.
I was skeptical too and didn't go to a larger tire til I was positive I wouldn't have to cut anything, etc. but I'm glad I finally got over it as my ride is higher, smoother, greater on cornering etc. Ford shoulda done this at the factory.
-AC