As loibl eluded to, the timing chain issue was never fully resolved. The situation with the guides and tensioners failing was improved around the '02 model year with updated guides and tensioners. Some owners never have an issue with their 4th gen Explorers, some do. If you do develop noise, you can start by replacing the external tensioners as soon as you start to hear it. Plenty of threads on here about how to do it, simple stuff really. Mine has 184k on the clock and I just replaced the factory external chain tensioners because mine started having a very light cold start rattle. So far, no more noise. Time will tell.
Other minor product improvements were done over the years. Nothing really noteworthy. The 5R55S transmissions hooked up to the 4.0L can be problematic. From my tech days, I remember getting some in with as little as 50k miles on them with extreme servo-bore wear. Others would come in at later mileage with VB issues, solenoid block issues, etc. Some failed from a simple lack of maintenance. Many of these transmissions last well past 100K miles with no issues until they just fail without warning. For me, once they hit 150k the expected service life has expired and any mileage you get out of them after that is just "gravy".
Again, my '06 EB has 184k on the clock and is running all of the factory powertrain gear. If something fails, it will bum me out and I will have to fix it. However, with the mileage I have on my Ex, it will be hard for me to blame it on "shoddy engineering". Vehicles are mechanical in nature, mechanical things have a service life then they break. Sometimes they break pre-maturely and that sucks for the person who owns it. Heck, sucks even when they have high mileage but a person needs the vehicle to be reliable as a daily driver. Just drive it, put back money every month for the "rainy day car fund" and enjoy it. These are pretty good vehicles and will last for quite some time with proper care and maintenance. Remember, vehicles are build by people on earth, not angles in heaven. They will break.
Hope this helps. Keep the bottom side down.