The rear main and the pan gasket leak, so it's best to replace both if you have the engine out and the means to pull the old seal and press in a new one.
You'll want to use something like the Fel-pro PTFE rubber rear main seal rather than just any old regular brand, including OE Motorcraft, since they will just continue to leak.
The crank sealing surface is super slick, too slick for a regular seal lip to do it's job, so it needs a better seal than what it came with.
There are also shim kits that put a paper-thin shim over the crank surface so it isn't so slick anymore, and let you use a regular seal again, but I'd use those as a last resort if even a PTFE seal doesn't seal it up.
You should also consider replacing the front crank seal, the timing chain, and I'd also suggest replacing the block expansion plugs with new brass ones.