What exactly are you planning on controlling that engine and tranny with?
Actually, I'll give you some helpful advice. The tranny for a 4.6 uses the same bolt pattern as any modular V8, which means the 5.0 coyote the newer f150 use bolt up to that tranny. Of course, you would need the ecu, harness, etc from an explorer with a 4.6.
The ecoboosts use the duratec bellhousing pattern, so you would actually be better off taking the tranny, ecu and harness from a ranger with a duratec....
Your REAL problem is controlling that ecoboost engine, since ford still hasn't released stand-alone controllers for the ecoboost, and shoehorning that sucker in. A 4.6 is a snug fitting engine in an explorer engine bay, and the 3.5 is dimensionally very similar, though not as long. The problem comes from the turbos, that take up quite a lot of real estate.
If you were to ever attempt this project, get yourself an explorer with a 4.6 and get a 5.0 coyote out of a wrecked mustang or f150, spend the $1500 on an engine control pack, and I'm sure there are plenty of members who would help you brainstorm how to integrate its signals into your current ECU and dash. Figure on your vehicle being out of service for 6 months to a year at minimum assuming you are a very competent mechanic and have a very large budget available.