I think bigger tires in general could add stress to a tranny no matter if you reclibrate the speedo or not...some people never recalibrate...some guys i have talked to didn;t know how to recalibrate and have been driving with the speedo off by like 4-5 MPH for years. It's just when you get bigger tires your truck and you both have to change your driving charectoristics. I know I can just tell when my truck will shift from the many years of driving it. Now when I go drive someone elses truck it feels like it's shifting wrong, when it isn't....it's just my perception. The truck has a momory that remembers your driving style and this memory changes. say you tow a trailer for 3,000 miles. The memory will change the shifting habits to account for the added weight. you take off the trailer it'll feel like it shifts different for a while. Saem thing with the tires. they are an added stress and if you drive on them for a while without recalibration, the truck's computer and you yourself will get used to it. i'm not saying thats the right thing to do, but personally I think it won;t do any damage to the tranny...all the tranny does is shift....the only thing that might not be good is if it was shifting in and out of overdrive a lot because of the added "weight", but thats all I can see happening.