Hey not a problem.. I believe the system takes 2 gal of fluid overall. I find that 50-50 with coolant/water is usually not a strong enough mixture when tested. I would pick up 2 gal of coolant and 1 gal of distilled water (mikeinri is right about the sediment and minerals) along with a coolant tester.
If you don't mind waiting a bit, there is a drain **** on the rad, its on the bottom corner on the passenger side. When you unscrew it, it wont come out b/c its captured in the hole, but fluid will come out...well it should. Depending on what condition everything is in, I've seen them totally clogged up with goo and nothing will come out. Its slow, but its easier to let it drain for a little while than fight with the hose. And take the cap off, it will drain faster (but leave it on while actually opening the drain, so less hot fluid runs down your arm)
To drain the overflow, just disconnect the hose from the rad and drop it down so the fluid can run out. If there's a bunch of crud in the bottom of the bottle, keep filling it and letting it drain, and it will flush out.
My procedure for filling it and getting the right mixture goes like this:
First put in the whole first gallon of antifreeze, then add distilled water to bring the level up to around the top of the rad. Then start and run the truck till the thermostat opens, with the heater on. Air will bubble out, and even more air will come out when the thermostat opens. Once the thermostat has opened, and you've topped it off to within reach of the tester, and let it run for a few min after that (ensuring that everything has blended together), test the antifreze with the tester. If it's too weak, then you will have to add some antifreze, if not then add more water. The tricky part is estimating how much to add to get the perfect mixture. If there is not enough left to fill to get the mixture right, then make the mixture in the overflow either very strong or very weak, and it will mix in during the drive cycle.
Now put the cap on and go for a drive. The vibration and whatnot from driving will force more air out of the system. Then leave it parked overnight.
The next day, double check the mixture and top off the bottle, which will have probably had most of its contents sucked into the rad. Use antifreze if its not strong enough, water if its too strong, or 50-50 if its good. Worst case, if its really off, you will have to siphon some off to make room for what is needed.
I think that this will help you a lot, cooling systems only work right when they have antifreze in them...
-Ted