I've run a bunch of different exhaust systems on my ex. Everything from stock, to straight pipes lightning style. I never noticed a major difference with any of them. I did feel a loss of power though with the straight pipes. Having a performance exhaust on these trucks is mainly for sound than performance. You may see some mileage gains, but HP and TQ gains are slim. I believe that if you go from stock to 2.25" you will see some minor gains, up to 2.5" your just gaining more sound and tone, after that you will likely start seeing some losses. In my experience, 2.5" is a good size to go with, gives you a good choice in mufflers, a good size to get a good tone, and doesn't have a negative impact on performance. The reason I like this muffler so much, is that it is the one that sounded the best to me.
Dan