fuses blow when there is a short circuit, or more that the allowable power is being pulled by a circuit to prevent fires and other damage.
did this happen without any modification to wiring harness?
Your brake wire is shorted to ground somewhere - fix that and it will start working again.
If you have messed with wiring (changed bulbs to faulty LED ones/added load resistors) start there.
I would say trailer connector also, but those bulbs are on separate fuses.
If you don't have an electrical background, take it in for service.