It can bind up and break an axle joint, d-shaft or t-case. Even though it's an open front diff the front d-shaft will have to spin faster than the rear. The open diff will balance out the speed difference of the left to right tire size difference and will actually be turning faster than if both tires were the same size. I'm not sure if that explanation makes sense? Think of it like this: If on the rear you had 35's, each tire will turn at 600 revolutions per mile. This mean that the differential will have 1200 revolutions put into it if you were to drag the truck for 1 mile. Now on the front you have a 35" tire on one side and a 33" tire on the other side. The 35" turns at 600 revolutions per mile and the 33" at 635 revolutions per mile. That is 1235 revolutions put into the front diff compared to only 1200 into the rear diff, therefore the front shaft will be turning faster. Make sense?