Mine has 130k, no mechanical problems at all. I'd do preventative measures, change diff fluids, transmission fluid and filter, PS fluid, bleed the brakes, transfer case, a tune up, etc.
You can check the ball joints, both upper and lower, they are common wear points.
Other than that, things that need to be checked depend on how you've used your truck.
The 5.0 engine and trans are rock solid drivetrains, I don't anticipate any problems for many miles.