No big secret...my ST is 2WD, I do a lot of highway travel, and very little off road use mosty at construction/landfill sites. I rotate them every 15k or so, keep them at right psi and had them balanced 3 times during their life. I could probably get another 10,000 miles out of them, and they would certainly pass a state inspection, but with it being close to winter, wanted fresh tread.
This may seem silly, but I believe it...don't turn unless the tires are rolling. Many people will start their turn before they start moving...this eats up the tread.
No. 1 way to get good miles on tires...drive like you have some sense...