Do yourself a favor and look for a V8. Fuel economy is very similar and the V8 engine and transmission is much more reliable. My V8's typically get around 16-17 city and up to 22-23 highway (your results may vary depending on where you live, traffic and how you drive). The AWD gets slightly less MPG than the 2WD (maybe 1-1.5 less MPG).
I currently own 1 SOHC V6 (has a rebuilt engine and trans) and had another a few years ago. Really have nothing good to ay about them. The OHV V6 is more reliable, but shares the same weak transmission and is down on power compared to the SOHC.
Owning/maintaining 4 V8's, they really don't have any weak points, just the usual wear items, which are easily replaced. The chassis parts are pretty much identical to the V6's. If you don't need/want the AWD, get the 2WD (less weight, slightly better MPG, easier to work on, less complexity = less to go wrong).