Run your power wires along the stock wire loom and the speaker/RCA wires along the opposite side. Whatever you do, don't run the wires down the tranny hump, across the "foot path" of the floor, across the cargo floor or anywhere they can be crushed by feet or cargo. Also, and to some this may sound stupid since the wires will be hidden. Put all your wires in split-loom. It will help with abrasion resistance and if done right, most people won't be able to tell your install from the stock wiring harness. It may be hidden, but you'll know its there and its done right.