I don't have the V8, but I felt the need to contribute...
I haven't done a whole lot of highway driving since I got my 50 SUV put on over the summer. I just brought my car back to school with me last weekend, and I took a trip up to my gf's college just yesterday. When you have the stereo cranked, it's not so bad- but driving up yesterday listening to O&A, it sounded like a small plane was trying to lift off when I hit 75 MPH! I love it around town, but on the highway, it makes me wish I had bigger tires or lower (numerically) gears or SOMETHING, cuz cruising speed puts it in the RPM range where it seems to resonate the most. However, if you are the kind of person who always drives 55, you might be okay.