I have the Fusion Sport which is the same CD4 as the new Edges. I'd check the tire profile on the Edge ST before making a decision. It is likely very thin for better steering response, which means it will pop like a balloon on any decent pothole. I lost 2 tires on my Fusion Sport because of the 235/40R19 tires. Southeast Michigan has the worst roads in America.
As for handling, I felt my 2018 Explorer XLT 4WD is "better" than the Fusion Sport overall. It won't outhandle the Fusion Sport (slalom, lateral grip, etc...), but the Explorer feels like only a slightly bigger and heavier Taurus SHO which feels more predictable to drive. When I over-rotate in a hard turn, the back end feels like it wants to swing out. On the Fusion Sport, even with the low profile sticky tires, the front tends to plow hard and never wants to over-rotate. I was driving on the sidewalls in the same turn that the SHO and Explorer XLT handled fairly well. The road racing experts are going to disagree with me, but if I had to do it again, I would never ever ever have gone with the Fusion Sport. I'd probably go with the Explorer Sport but the lack of the twin-turbos hasn't been a big deal for what I use my XLT.
Also, the 2.7L EcoBoost is not very good, just like the Fusion Sport. The 2.7 has almost no low end torque with the stock tune. It lags badly. I have trouble passing Silverados and an EcoBoost Mustang will walk and gap the Fusion Sport. Power braking does nothing as it just plain bogs off the line, and the 6F55 tune from the factory takes forever to shift. My tuned SHO takes off like a missile and the 6F55 with only minor minor tweaks, shifts very quickly just like the stock 6F55 in my 2018 XLT. Heck, the stock SHO and my XLT launches better than the Fusion Sport. There's no replacement for displacement, and the 3.5 EcoBoost is a better engine.
The CD4 interior is more modern, shiny, and updated compared to the dated D3/D4 interior... but I feel absolutely at home in the D3/D4. Even with the base XLT seats in the Explorer.
Just my 2 cents.