I have had this and other related Navigation problems. Seems the system will, at times, take a very, very long time to catch satilites - 10 minutes or more. Looses the connection on occasion, causing your type of problem. Also, I find when on a lengthly trip, the Navigation may show 3 hours remaining. If I stop and restart the car, the route picks up but now the time remaining may be 7 hours. To get the correct arrival time, I need to cancle the route, and reprogram it from Previous Destination. On a few occasions, in the middle of a trip, a verbal message "Navigation Failed" is announced and the destination is discontinued. Usually, reprogramming it works.
When traveling on long trips, I have learned to carry my trusty Magellen portable navigation system with me. Just can't trust that the Explorer will work when I need it most. Interesting that a $200 Magellen works more reliably, can be programmed with address from my laptop computer, and pick up the satalites more reliably than a car I paid over $40K for. These problems never happen on any of my other Honda's that I have owned over the years.