4ga is fine, for 7-10ft runs. More than that, i'd be looking to get 1/0 wire back and put a distribution block in.
Dual voice coil subs are a funny beast. A 2ohm dual voice coil sub is really a 4ohm sub, because if you use a monoblock, you wire the second voice coil in series with the first. I've never hooked up just one side of a dual voice coil sub, so i don't know what it would do. (require 1/2 the power probably)
Mono amps just mean that there is brute power comming out of the speaker terminals. It doesn't have to split and stage the audio to diffrent paths. They're just one giant amp. They give you 2 sub hookups, and they consider it in series. So if you have 2 subs that want 500w each, at 2 ohms, the JBL provides 1100 watts x1 @ 2ohms, or 550w x2 @2 ohms. (roughly in half). Multi channel/2 channel amps have 2 physically seprate stages, so the subs are paralell.
It is true some amps only have 1 set of terminals, so be careful if you look into monoblocks. Do some homework before buying an amp. Make sure it has everything you want.
The nice thing about monoblocks / Class D amps is, they can get the lower frequencies better than say AB class. The JBL for instance can get to 20hz, whereas that MA Audio can only get down to 32hz. May not be a big diffrence, but if you're going for SQ, that'd make the diffrence.
Also, if you're going for a monoblock, look into a cap of some kind, or if you have a powerful alt in your truck, that should do. monoblocks, (like the JBL) can draw upwards of 300A peak! (YEEK!)... The JBL's also have 3 30A fuses in them, just to give you an idea of what kind of power they're capable of.
EDIT: Oops, meant to say 115A peak. That's still a ****load of power!
