This is a 4.6l engine symptom. No one to my knowledge has ever directly found the cause. I can tell you for certain, it isn't due to Cold Air Intakes or filters of the such.
Mine does it at times, yet I don't suffer any MPG's so I'm not sure it's an issue other than the sound is annoying.
To me, it's the sound caused by air flowing over an object with an edge to it. Perhaps when the throttle air valve is tilted at a specific angle and the air is coming across it?