My 2005 has about 323,450 on it right now. My engine went in March at 299,798. Replaced it and put about 23,500 on it already. As you can see I do a LOT driving. The only real problems that I seem to have are the bearings and the blend door. I have replaced the bearings in each wheel, 2x already and getting set to do it again. My blend door originally went in November 2010. I paid $978 to have it replaced, but it only lasted until the end of April 2011. My brother and I replaced it in August of 2011 (with Big Rondo's help from here) and it's just starting to go again. I've been pretty neglectful with the tuneups though. Did my first 1 at about 190,000 and haven't done it since. Don't ask why, I don't know. But she starts faithfully every day, without any problems. The only problem I seem to have is with the struts. I replaced the original struts in February with Strutteks. They don't seem to work for me like they do for everyone else on here. I don't feel like my truck hugs the curves or grips the road like she used to. I'm looking into replacing them before winter kicks in with the original Motorcrafts if I can find someplace to buy them, other than at Fordparts.com